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This could be a datastore level configuration I guess, but we could also make it a per feature type one using a design such as the one described here:
http://www.nabble.com/Re%3A--Geoserver-devel--Updatable-Postgis-Views-with-WFS-and-Geoserver-p26054300.html
As to how to treat the columns in WFS-T, that is a bit hairy. We could treat the columns as read only, or try to use them as the pk values if the strategy for PK treatment is "user assigned".